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Published on: January 14, 2014
[Cytogenetic aberrations in histologically benign infiltratively growing sphenoid wing meningiomas]
Abstract:
Meningiomas of the sphenoid wing (SW) frequently show an invasive pattern of growth and cause destruction of the adjacent structures. As a result, the rate of recurrent SW meningiomas is as high as 30%. Cytogenetic investigations showed no aberrations specific to invasively growing meningiomas. During this study, the authors evaluated 10 invasive and 5 non-invasive SW meningiomas via comparative genome hybridization (CGH) (matrix CGH), by using the gene chips of GenoSensor Array micromatrixes. The mean number of aberrations in the tumor cells was much greater in case of invasive meningiomas (67.4 versus 40.5 in case of non-invasive SW meningiomas. Furthermore, in invasive SW meningiomas, there were frequently losses in loci 1p, 6q, and 14q and gains in loci 15q and 10, which had been predetermined as molecular markers of stepwise progression of meningioma. Thus, the presence of a complex cytogenetic profile and progression-associated chromosome aberrations in benign SW meningiomas is linked with the increase of their invasive potential. Due to the fact that there are no well-defined adjuvant therapy regimens for recurring meningiomas at present, the revealed genomic aberrations may become potential targets for searching for drugs and a therapeutic intervention in future.
Insights
Sphenoid wing meningiomas with invasive growth show more genetic changes. Specific chromosome aberrations in these benign tumors may predict invasiveness and guide future therapies for recurrent meningiomas.
Area of Science:
- Neuro-oncology
- Genetics
- Oncology
Context:
- Sphenoid wing meningiomas (SW) often exhibit invasive growth, leading to adjacent structure destruction and high recurrence rates (up to 30%).
- Previous cytogenetic studies have not identified specific aberrations linked to invasive meningiomas.
- Comparative Genome Hybridization (CGH) using gene chips offers a high-resolution method for genomic analysis.
Purpose:
- To investigate the genomic profiles of invasive and non-invasive sphenoid wing meningiomas using matrix CGH.
- To identify potential molecular markers associated with the invasive potential and progression of SW meningiomas.
- To explore the implications of genomic aberrations for future therapeutic strategies against recurrent meningiomas.
Summary:
- Comparative Genome Hybridization (CGH) analysis revealed a significantly higher mean number of genomic aberrations in invasive SW meningiomas (67.4) compared to non-invasive ones (40.5).
- Invasive meningiomas frequently displayed losses at loci 1p, 6q, and 14q, and gains at loci 15q and 10, which are known markers of meningioma progression.
- A complex cytogenetic profile and specific progression-associated chromosomal aberrations correlate with increased invasive potential in benign SW meningiomas.
Impact:
- Identified genomic aberrations in SW meningiomas may serve as potential molecular markers for invasiveness and tumor progression.
- These findings could guide the development of targeted therapies for recurrent meningiomas, addressing the current lack of well-defined adjuvant treatment regimens.
- Provides a basis for future research into novel drug targets and therapeutic interventions for aggressive meningioma subtypes.
