[Effect of preoperative transcatheter arterial chemo-embolization on activity of cell proliferation in Wilms; tumor]
Wei-guang Liu1, Wei-zhong Gu, Yin-bao Zhou
1The Affiliated Children's Hospital, College of Medcine, Zhejiang University, Hangzhou 310003, China.
Objective:
To investigate the effect of preoperative transcatherter arterial chemo-embolization (TACE) on the cell proliferation in Wilms; tumor.
Methods:
Forty-one cases of Wilms; tumor diagnosed by histopathology were divided into two groups: in TACE group, 23 patients received TACE first and were operated 2 weeks later; in control group, 18 patients were operated alone. A comparative analysis of the pathological finding was made in two groups, and the expression of PCNA and VEGF in tumor tissue was detected by immunohistochemistry.
Result:
The degeneration of tumor tissue such as tumor cell necrotic, broken, disappearance occurred in 17 cases of TACE group and in 4 cases of control group, respectively (P <0.01). The expression of PCNA in TACE group and in control group was 1/23 (4.3 %) and 9/18(50.0 %), respectively (P <0.01). VEGF was expressed in 7/23 (30.4 %) of TACE group and 9/18 (50.0 %) of control group (P=0.283).
Conclusion:
TACE can significantly inhibit proliferation and enhance degeneration of Wilms; tumor cells.
