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Updated: Jul 7, 2026

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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
Synthesis of alpha-CF2-mannosides and their conversion to fluorinated pseudoglycopeptides
Florent Poulain1, Anne-Lise Serre, Jérôme Lalot
1Université et INSA de Rouen, CNRS, UMR 6014 C.O.B.R.A.-IRCOF, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France.
The Journal of Organic Chemistry
|February 16, 2008
Abstract:
A methodology allowing the synthesis alpha-CF(2)-mannosides, based on the addition of a difluoroenoxysilane to a glycal followed by a dihydroxylation reaction, is described. The resulting 2,2-difluoro-2-mannosylacetate is converted into two pseudoglycopeptides which may act as E- and P-selectin inhibitors.

