Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nano-engineering the titanium-tissue interface: a 15 year perspective on bio-functionalization and surface innovation.

Nanoscale advances·2026
Same author

Towards intelligent and miniaturized drug delivery devices.

Nature·2026
Same author

Electrosprayed Magnetic Poly(butyl methacrylate-<i>co</i>-(2-dimethylaminoethyl) methacrylate-<i>co</i>-methyl methacrylate)/Iron Oxide Microparticles for Efficient Curcumin Delivery.

ACS omega·2026
Same author

Tanfloc and carboxymethyl-kappa-carrageenan polyelectrolyte multilayers impart antithrombotic activity, enhanced re-endothelialization and antimicrobial activity on blood-contacting materials.

Biomaterials advances·2026
Same author

Carboxymethyl kappa carrageenan polyelectrolyte multilayers as blood contacting surfaces.

Discover biotechnology·2025
Same author

Bacterial adhesion and erythrocyte integrity on polycaprolactone nanowire surfaces.

RSC advances·2025

Related Experiment Video

Updated: Jul 7, 2026

Micromechanical Tension Testing of Additively Manufactured 17-4 PH Stainless Steel Specimens
05:38

Micromechanical Tension Testing of Additively Manufactured 17-4 PH Stainless Steel Specimens

Published on: April 7, 2021

Surface modification of SU-8 for enhanced biofunctionality and nonfouling properties.

Sarah L Tao1, Ketul C Popat, James J Norman

  • 1Department of Physiology, Division of Bioengineering, University of California-San Francisco, San Francisco, California 94158, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|February 16, 2008
PubMed
Summary

Researchers modified SU-8, a semiconductor material, with poly(ethylene glycol) (PEG) to enhance its biocompatibility. This surface modification reduced protein adsorption and improved cell attachment, expanding SU-8

More Related Videos

Preparation and High-temperature Anti-adhesion Behavior of a Slippery Surface on Stainless Steel
10:52

Preparation and High-temperature Anti-adhesion Behavior of a Slippery Surface on Stainless Steel

Published on: March 29, 2018

Pattern Generation for Micropattern Traction Microscopy
09:26

Pattern Generation for Micropattern Traction Microscopy

Published on: February 17, 2022

Related Experiment Videos

Last Updated: Jul 7, 2026

Micromechanical Tension Testing of Additively Manufactured 17-4 PH Stainless Steel Specimens
05:38

Micromechanical Tension Testing of Additively Manufactured 17-4 PH Stainless Steel Specimens

Published on: April 7, 2021

Preparation and High-temperature Anti-adhesion Behavior of a Slippery Surface on Stainless Steel
10:52

Preparation and High-temperature Anti-adhesion Behavior of a Slippery Surface on Stainless Steel

Published on: March 29, 2018

Pattern Generation for Micropattern Traction Microscopy
09:26

Pattern Generation for Micropattern Traction Microscopy

Published on: February 17, 2022

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Nanotechnology

Background:

  • SU-8, an epoxy-based negative photoresist, is widely used in semiconductor manufacturing.
  • Its hydrophobic nature limits biomedical applications due to nonspecific biomolecule adsorption and poor cell attachment.
  • Surface modification is crucial for enhancing SU-8's biofunctionality.

Purpose of the Study:

  • To covalently attach poly(ethylene glycol) (PEG) to the SU-8 surface.
  • To improve SU-8's nonfouling properties and enhance cell attachment.
  • To investigate the effect of varying PEG molecular weights and concentrations on surface properties.

Main Methods:

  • Surface modification of SU-8 by grafting poly(ethylene glycol) (PEG).
  • X-ray photoelectron spectroscopy (XPS) to verify PEG attachment and analyze surface composition.
  • Calculation of PEG film thickness using a standard overlayer model.
  • Assessment of protein adsorption and fibroblast interactions on modified SU-8 surfaces.

Main Results:

  • Successful covalent attachment of PEG to SU-8 surfaces was confirmed by XPS.
  • Higher PEG grafting densities were achieved with increased concentration and immobilization time.
  • PEG modification effectively reduced nonspecific protein adsorption.
  • Improved fibroblast attachment and interaction were observed on PEG-modified SU-8.

Conclusions:

  • Surface chemistry modification of SU-8 with PEG significantly enhances its biofunctionality.
  • PEGylated SU-8 exhibits improved nonfouling properties and better cell adhesion.
  • This approach holds promise for expanding SU-8's utility in biomedical applications such as tissue engineering and biosensing.