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Related Experiment Videos

Platelet activation in nocturnal asthma.

J F Morrison1, S B Pearson, H G Dean

  • 1Respiratory Function Laboratory, Killingbeck Hospital, Leeds.

Thorax
|March 1, 1991
PubMed
Summary

Platelet activation increases at night in asthma patients, correlating with lower peak expiratory flow. This nighttime platelet activation is not linked to plasma catecholamines or reversed by atropine, suggesting parasympathetic nerves aren't responsible.

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Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Circadian Rhythms

Background:

  • Bronchial hyperresponsiveness is a hallmark of asthma.
  • This hyperresponsiveness often worsens at night.
  • Platelet activation is a potential contributing factor to asthma severity.

Purpose of the Study:

  • To investigate the diurnal variation of platelet activation in asthma patients.
  • To correlate platelet activation with peak expiratory flow and plasma catecholamines over 24 hours.
  • To assess the effect of muscarinic receptor blockade on nighttime platelet activation.

Main Methods:

  • Studied five asthma patients and five normal subjects over 24 hours.
  • Measured platelet activation using the ratio of beta-thromboglobulin to platelet factor 4.

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  • Administered intravenous atropine at 0400 hours to assess parasympathetic activity's role.

    • Main Results:

    • Platelet activation peaked when peak expiratory flow was lowest in asthmatic subjects.
    • No correlation was found between platelet activation and plasma catecholamine levels.
    • Atropine administration did not affect the platelet activation ratio.

    Conclusions:

    • Nighttime increases in platelet activation in asthma are linked to reduced airflow, not plasma catecholamines.
    • Parasympathetic nervous system activity does not appear to drive increased nighttime platelet activation in asthma.