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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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Imaging host-pathogen interactions

Laura Campisi1, Frédéric Brau, Nicolas Glaichenhaus

  • 1Institut National de la Santé et de la Recherche Médicale U924, Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France.

Immunological Reviews
|February 16, 2008
PubMed

Imaging techniques have been revolutionized by advancements in both microscope instrumentation and data collection processing software. Immunologists and microbiologists now have access to a large panel of powerful technologies that are characterized by different spatial and time resolutions. In this review, we discuss recent studies in which emerging imaging technologies have been used to decipher the complexity of the interactions between pathogens and their mammalian hosts. By focusing on two very different pathogens, Plasmodium and Salmonella, we emphasize the critical role of imaging studies in the understanding of the host's immune system response to a pathogen.

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