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Updated: Jul 7, 2026

10:59
Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
Published on: May 24, 2017
Structural insights into DNA lesion bypass
Structure (London, England : 1993)
|February 16, 2008
Abstract:
A number of highly specialized DNA polymerases with the ability to replicate through DNA lesions have been identified. In this issue of Structure, Nair et al. show how one such polymerase, yeast Rev1, accomplishes the DNA lesion bypass task.
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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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