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Related Experiment Videos

Pleural effusion in aneuploidy.

B M Petrikovsky1, S M Shmoys, D A Baker

  • 1Department of Obstetrics and Gynecology, State University of New York, Stony Brook 11794-8091.

American Journal of Perinatology
|May 1, 1991
PubMed
Summary
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Isolated pleural effusion in aneuploid fetuses, including trisomy 13, is reported. Karyotyping is crucial before in utero treatment for pleural effusion to guide prognosis and management.

Area of Science:

  • Fetal Medicine
  • Genetics
  • Neonatal Care

Background:

  • Pleural effusion in fetuses can indicate underlying aneuploidy.
  • Early diagnosis and intervention are critical for fetal outcomes.
  • Fetal hydrops associated with pleural effusion often has a poor prognosis.

Observation:

  • Three consecutive cases of isolated pleural effusion in aneuploid fetuses were observed.
  • Pleural effusion in trisomy 13 fetuses has not been previously documented.
  • The timing of pleural effusion development impacts prognosis and treatment options.

Findings:

  • Aneuploidy, specifically trisomy 13, can manifest as isolated pleural effusion.
  • Late-onset pleural effusion may be amenable to in utero intervention.

Related Experiment Videos

  • Karyotyping is essential for accurate diagnosis and risk assessment.

    • Implications:

    • Karyotype analysis is recommended for all fetuses with pleural effusion before considering in utero pleuroamniotic shunting.
    • This finding expands the spectrum of fetal aneuploidy presentations.
    • Timely genetic diagnosis can inform management strategies and improve counseling for affected families.