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Related Experiment Video

Updated: Jul 7, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

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Plant-derived compounds in clinical trials.

Arvind Saklani¹, Samuel K Kutty

¹Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, SAS Nagar 160062, Punjab, India. asaklani@nicholaspiramal.co.in

Drug Discovery Today

|February 16, 2008

Summary

Plants are a vital source for new drug discovery, particularly for anticancer and anti-infectious agents. This review details 91 plant-derived compounds in clinical trials as of 2007, highlighting their ongoing contribution to medicine.

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Area of Science:

Ethnobotany and Phytochemistry
Drug Discovery and Development
Medicinal Plant Research

Background:

Plants have historically served as a crucial reservoir for novel therapeutic compounds.
Plant-derived natural products have significantly contributed to modern medicine, especially in oncology and infectious diseases.
The continuous exploration of plant-based resources is essential for identifying new drug leads.

Purpose of the Study:

To review plant-derived compounds currently in clinical trials.
To summarize the progress of plant-based drug discovery up to September 2007.
To provide an overview of plant-derived drugs launched between 2000 and 2006.

Main Methods:

Literature review of scientific databases and clinical trial registries.
Compilation and analysis of data on plant-derived compounds in clinical development.
Summary of recently launched plant-based pharmaceuticals.

Main Results:

Identified 91 distinct plant-derived compounds undergoing clinical trials as of September 2007.
Highlighted the prevalence of anticancer and anti-infectious agents among these compounds.
Cataloged plant-based drugs approved and marketed between 2000 and 2006.

Conclusions:

Plant-derived compounds remain a significant and ongoing source for new drug candidates.
The pipeline of plant-based therapeutics, particularly for cancer and infections, is robust.
Continued research into phytochemistry is vital for future pharmaceutical innovation.