Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Heart Disease: Overview

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Managing "socially admitted" patients in hospital: a qualitative study of health care providers' perceptions.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2024

Same author

Wherefore Frailty: An Opportunity to Improve Cardiac Care.

The Canadian journal of cardiology·2024

Same author

Feasibility and acceptability of NIDUS-professional, a training and support intervention for homecare workers caring for clients living with dementia: a cluster-randomised feasibility trial.

Age and ageing·2024

Same author

A systematic review of goal attainment scaling implementation practices by caregivers in randomized controlled trials.

Journal of patient-reported outcomes·2024

Same author

Levels of frailty and frailty progression in older urban- and regional-living First Nations Australians.

Maturitas·2024

Same author

A 10-week intergenerational program bringing together community-living older adults and preschool children (INTERACTION): a pilot feasibility non-randomised clinical trial.

Pilot and feasibility studies·2024

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Vascular cognitive impairment: current concepts and clinical developments.

Paige Moorhouse¹, Kenneth Rockwood

¹Division of Geriatric Medicine, Halifax, Nova Scotia, Canada.

The Lancet. Neurology

|February 16, 2008

Summary

Vascular cognitive impairment (VCI) is a spectrum of cognitive disorders linked to cerebrovascular disease. Research highlights the need for standardized criteria to study VCI

More Related Videos

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Related Experiment Videos

Last Updated: Jul 7, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Area of Science:

Neurology
Neuroscience
Gerontology

Background:

Vascular cognitive impairment (VCI) encompasses cognitive disorders stemming from cerebrovascular disease, largely superseding the term multi-infarct dementia.
While heterogeneous, VCI presents discernible clinical patterns, allowing for recognition of subtypes like mixed dementia and VCI-no dementia.

Purpose of the Study:

To address the need for harmonized standards in studying the diverse manifestations of VCI.
To inform the development of diagnostic criteria that encompass the full spectrum of VCI.
To re-evaluate the role of executive dysfunction in VCI and explore potential preventative strategies.

Main Methods:

Review of existing literature on VCI and cerebrovascular disease.
Analysis of clinical patterns and subtypes within the VCI construct.
Examination of current diagnostic criteria for vascular dementia in relation to VCI.

Main Results:

Existing diagnostic criteria for vascular dementia do not fully capture the VCI construct.
Executive dysfunction, while a feature, may not be as exclusive to VCI as previously thought.
Evidence suggests VCI may be preventable, though less robust than stroke prevention data.

Conclusions:

Harmonized standards are crucial for studying VCI's varied presentations and developing accurate diagnostic criteria.
Future VCI research should carefully consider clinical features and outcomes when investigating specific therapies.
Further investigation is needed to confirm the preventability of VCI and refine therapeutic approaches.