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A Planarian Motility Assay to Gauge the Biomodulating Properties of Natural Products
Published on: May 30, 2020
Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians
Amanda L Rowlands1, Oné R Pagán
1Department of Biology, West Chester University, West Chester, PA 19383-2112, USA.
European Journal of Pharmacology
|February 16, 2008
Abstract:
We recently reported that parthenolide and related sesquiterpene lactones are able to prevent and reverse behavioral responses in planarian worms induced by acute cocaine exposure. Previous reports indicate that when planarians are chronically exposed to microM concentrations of cocaine, they display stereotypical withdrawal-like behaviors when the cocaine is removed. Here we report that parthenolide prevents this cocaine-induced expression of planarian withdrawal-like behaviors.

