Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Implications of the 21st Century Cures Act in Pediatrics.

Pediatrics·2020

Same author

High prevalence of same-sex twins in patients with cloacal exstrophy: Support for embryological association with monozygotic twinning.

Journal of pediatric surgery·2017

Same author

Growth morbidity in patients with cloacal exstrophy: a 42-year experience.

Journal of pediatric surgery·2016

Same author

Understanding the Operative Experience of the Practicing Pediatric Surgeon: Implications for Training and Maintaining Competency.

JAMA surgery·2016

Same author

What is the optimal treatment for children with primary hyperparathyroidism?

Journal of pediatric surgery·2010

Same author

Portal vein thrombus after pediatric proctocolectomy with ileoanal anastomosis.

Journal of pediatric surgery·2010

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

Omental lipoblastoma.

Stephanie A Koplin¹, Matthew H Twohig, Dennis P Lund

¹Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, CSC-3224, 600 Highland Avenue, Madison, WI 53792, USA.

Pathology, Research and Practice

|February 16, 2008

Summary

This case report details an unusual omental lipoblastoma in a 6-month-old boy, characterized by a rare chromosomal translocation t(8;14)(q13;q24). The findings highlight the importance of genetic analysis in diagnosing pediatric lipoblastomas and differentiating them from other soft tissue tumors.

More Related Videos

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Published on: January 29, 2021

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Related Experiment Videos

Last Updated: Jul 7, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Published on: January 29, 2021

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Area of Science:

Pediatric Oncology
Surgical Pathology
Cytogenetics

Background:

Lipoblastomas are rare, benign tumors of infancy and childhood composed of immature fat cells (lipoblasts).
Omental involvement is uncommon, with only a few cases previously reported in the literature.
Genetic abnormalities, particularly involving chromosome 8q, are characteristic of lipoblastomas.

Observation:

A large intra-abdominal mass was discovered in a 6-month-old boy during a routine examination.
Imaging revealed a solid mass initially suspected to be of hepatic origin but surgically found in the omentum.
Histological examination confirmed the diagnosis of lipoblastoma based on the presence of varying stages of adipocytes.

Findings:

Cytogenetic analysis revealed an unusual karyotype: 46,XY,t(8;14)(q13;q24).
This translocation involves chromosome 8q, consistent with lipoblastomas, but the fusion partner 14q24 is highly atypical.
The tumor was successfully surgically excised, and its differentiation from myxoid liposarcoma was a key diagnostic consideration.

Implications:

This case expands the understanding of the cytogenetic spectrum of lipoblastomas.
The unusual translocation highlights the need for comprehensive genetic analysis in diagnosing pediatric soft tissue tumors.
Accurate diagnosis is crucial for appropriate management and to distinguish benign lipoblastomas from potentially malignant neoplasms.