ML parameter estimation for Markov random fields with applications to Bayesian tomography
Related Experiment Video
Updated: Jul 7, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
S S Saquib1, C A Bouman, K Sauer
1Polaroid Corp., Cambridge, MA 02139, USA. saquibs@polaroid.com
Abstract:
Markov random fields (MRF's) have been widely used to model images in Bayesian frameworks for image reconstruction and restoration. Typically, these MRF models have parameters that allow the prior model to be adjusted for best performance. However, optimal estimation of these parameters(sometimes referred to as hyper parameters) is difficult in practice for two reasons: i) direct parameter estimation for MRF's is known to be mathematically and numerically challenging; ii)parameters can not be directly estimated because the true image cross section is unavailable.In this paper, we propose a computationally efficient scheme to address both these difficulties for a general class of MRF models,and we derive specific methods of parameter estimation for the MRF model known as generalized Gaussian MRF (GGMRF).The first section of the paper derives methods of direct estimation of scale and shape parameters for a general continuously valued MRF. For the GGMRF case, we show that the ML estimate of the scale parameter, sigma, has a simple closed-form solution, and we present an efficient scheme for computing the ML estimate of the shape parameter, p, by an off-line numerical computation of the dependence of the partition function on p.The second section of the paper presents a fast algorithm for computing ML parameter estimates when the true image is unavailable. To do this, we use the expectation maximization(EM) algorithm. We develop a fast simulation method to replace the E-step, and a method to improve parameter estimates when the simulations are terminated prior to convergence.Experimental results indicate that our fast algorithms substantially reduce computation and result in good scale estimates for real tomographic data sets.
Related Concept Videos
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Noncompartmental Analysis: Statistical Moment Theory
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...

