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Updated: Jul 7, 2026

Isolating Lymphocytes from the Mouse Small Intestinal Immune System
Published on: February 28, 2018
Immunoproliferative small intestinal disease with protein loss complicated with duodenal T cell lymphoma during
Takeshi Hara1, Hisashi Tsurumi, Tomohiro Kato
1The First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Abstract:
A 52-year-old man was admitted to our hospital in October 2001 with abdominal pain. Abdominal X-ray indicated a diagnosis of ileus. Histopathological and immunological examination resulted in a diagnosis of immunoproliferative small intestinal disease (IPSID). He was treated with THP-COP therapy (pirarubicin, cyclophosphamide, vincristine, and prednisolone), which resulted in complete remission. Outpatient follow-up revealed hypoalbuminemia in May 2003 and upper gastrointestinal endoscopy showed duodenal mucosal nodularity. He was diagnosed with relapsed IPSID and salvage chemotherapy was started. Follow-up endoscopy confirmed that the therapy was effective, but uncovered another duodenal mucosal nodularity. Immunohistochemical staining revealed T-cell lymphoma. Chemotherapy was discontinued and the patient died in December 2004.
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