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Updated: Jul 7, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Plastic bronchitis: a management challenge.

Michael H Eberlein¹, Michael B Drummond, Edward F Haponik

¹Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA. meberle3@jhmi.edu

The American Journal of the Medical Sciences

|February 16, 2008

Summary

Plastic bronchitis involves coughing up large, branching bronchial casts. This case highlights idiopathic plastic bronchitis, emphasizing the need for better understanding and treatment of this rare airway condition.

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Last Updated: Jul 7, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

Pulmonology
Respiratory Medicine

Background:

Plastic bronchitis is a rare condition characterized by the expectoration of bronchial casts.
It can range from small segmental casts to complete airway obstruction, posing a life-threatening emergency.

Observation:

A case of a 39-year-old woman with idiopathic plastic bronchitis presenting with episodic wheezing and severe dyspnea.
The patient expectorated large, thick, branching secretions described as 'squid-like'.

Findings:

Bronchial casts in plastic bronchitis are classified as type I (inflammatory) or type II (acellular).
While systemic illnesses can be associated, many cases, like this one, are idiopathic.
Treatment focuses on acute cast removal and addressing the hypersecretory process, though evidence is largely anecdotal.

Implications:

The rarity and heterogeneity of plastic bronchitis limit systematic treatment investigations.
Further understanding of mucus production regulation could lead to novel therapeutic strategies for plastic bronchitis and other mucus hypersecretory lung diseases.