Related Experiment Video
Updated: Jul 7, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
Focal segmental glomerulosclerosis: recent advances
1Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. mpollak@rics.bwh.harvard.edu
Purpose Of Review:
Focal segmental glomerulosclerosis is a significant and growing cause of chronic kidney disease and nephrotic syndrome in adults and children.
Recent Findings:
The last year has seen continued progress in understanding podocyte biology, mechanisms of podocyte dysfunction, and its contribution to proteinuria and focal segmental glomerulosclerosis.
Summary:
A number of studies have helped to elucidate the mechanisms of slit-diaphragm-mediated signaling to the podocyte cytoskeleton. Advances in treatment continue to lag behind advances in understanding focal segmental glomerulosclerosis disease biology.

