Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mania and Antimanic Drugs: Overview

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...

Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

Bipolar Disorder

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Psychosis: Goals of Pharmacotherapy

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sanitizer Efficacy Against Attached Bacteria in a Milk Biofilm.

Journal of food protection·2019

Same author

The Effect of Sublethal Heat Shock and Growth Atmosphere on the Heat Resistance of Listeria monocytogenes Scott A.

Journal of food protection·2019

Same author

Evaluation of a Dry Medium Culture Plate (3M Petrifilm AC) for Laboratory Pasteurized Counts.

Journal of food protection·2019

Same author

Increase in Heat Resistance of Listeria monocytogenes Scott A by Sublethal Heat Shock.

Journal of food protection·2019

Same author

Estimation of Potential Shelf-life of Pasteurized Fluid Milk Utilizing a Selective Preliminary Incubation.

Journal of food protection·2019

Same author

Selective Preliminary Incubation for Gram-Negative Psychrotrophic Bacteria in Milk.

Journal of food protection·2019

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Complementary medicines in pediatric bipolar disorder.

S Bogarapu¹, J R Bishop, C D Krueger

¹Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA.

Minerva Pediatrica

|February 16, 2008

Summary

Complementary and alternative medicines (CAM) are increasingly used for pediatric bipolar disorder. While some CAM like Omega-3s show promise as adjunctive treatments, conventional medicine remains the primary choice.

Related Experiment Videos

Last Updated: Jul 7, 2026

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

Psychiatry
Pediatric Mental Health
Complementary and Alternative Medicine (CAM)

Background:

Growing use of CAM for mental health conditions, especially in children.
Challenges in pediatric mental illness treatment drive interest in alternatives.
Increased CAM utilization in psychiatry for difficult-to-treat conditions like pediatric bipolar disorder (BD).

Purpose of the Study:

To review studies on the utility of CAM in bipolar disorder patients.
To inform healthcare providers about CAM use in pediatric patients.
To assess the efficacy and role of CAM in managing pediatric bipolar disorder.

Main Methods:

Literature review of studies investigating CAM in bipolar patients.
Selection of relevant studies for analysis.
Synthesis of findings on specific CAM interventions.

Main Results:

Omega-3 fatty acids and lecithin/choline show preliminary potential for bipolar disorder treatment.
S-adenosyl methionine (SAM-e) and inositol have data supporting efficacy in depressive symptoms.
CAM may serve as useful adjunctive treatments, but limited data supports standalone therapy.

Conclusions:

Conventional medicines remain the first-line treatment for pediatric bipolar disorder.
Healthcare providers must inquire about and understand the risks and benefits of CAM in children.
Further research is needed to establish the role of CAM as standalone therapy.