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Updated: Jul 7, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from

Wolfgang Bergmeier1, Anil K Chauhan, Denisa D Wagner

  • 1Cardeza Foundation and Department of Medicine, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19007, USA. wolfgang.bergmeier@jefferson.edu

Thrombosis and Haemostasis
|February 19, 2008
PubMed

The von Willebrand factor (VWF) receptor complex, glycoprotein (GP)Ib-V-IX, and its main ligand VWF play a key role in the adhesion process of platelets to sites of vascular injury. Recent studies in mutant mice have shed new light on the importance of either molecule for the development of arterial and venous thrombosis. In this review, we summarize the most important aspects from these studies.

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