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Updated: Jul 7, 2026
Murine Model of Intestinal Ischemia-reperfusion Injury
Published on: May 11, 2016
The ischemic preconditioning and postconditioning effect on the intestinal mucosa of rats undergoing mesenteric
Carlos Henrique Marques Dos Santos1, Otoni Moreira Gomes, José Carlos Dorsa Vieira Pontes
1Surgery Department, UFMS, Campo Grande, Mato Grosso do Sul, Brazil. chmarques@terra.com.br
Purpose:
To evaluate the effect of the ischemic preconditioning and the ischemic postconditioning over the tissue injury in the intestinal mucosa of rats undergoing the procedure of mesenteric ischemia and reperfusion.
Methods:
Thirty Wistar rats were studied, divided in three groups: group A, undergoing mesenteric ischemia (30 minutes) and reperfusion (60 minutes); group B, mesenteric ischemia and reperfusion preceded by ischemic preconditioning; group C, mesenteric ischemia and reperfusion and, before the beginning of reperfusion, the ischemic postconditioning was performed. At the end, a segment of the small intestine was dissected for histological analysis. The results were evaluated using the CHIU et al.6 classification followed by the statistic treatment.
Results:
The mean values of the tissue injury levels were: group A, 3.5; group B, 1.2; and group C, 1. The difference between the result of group A with the results of groups B and C was considered statistically significant (p < 0,05).
Conclusion:
The ischemic preconditioning and postconditioning are able to minimize the tissue injury in the intestines of rats that underwent the procedure of mesenteric ischemia and reperfusion.
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