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Updated: Jul 7, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Preventing intraperitoneal adhesions with vitamin E and sodium hyaluronate/carboxymethylcellulose: a comparative
Fredy Corrales1, Marcelo Corrales, Carlos Cauduro Schirmer
1HG, UCS, Caxias do Sul, Brazil. clindig@uol.com.br
Purpose:
To compare the effectiveness of intraperitoneally administered vitamin E with the sodium hyaluronate/carboxymethylcellulose membrane (HA/CBMC) in preventing postoperative intraperitoneal adhesion formation.
Methods:
Sixty Wistar rats underwent a laparotomy and adhesions were induced (IA). The animals were divided into four groups: group 1, control (IA); group 2 (IA + Vitamin E): group 3 (IA+HA/CBMC) and group 4 (IA+ Vitamin E + HA/CBMC). The Vitamin E (groups 2 and 4) and HA/CBMC (groups 3 and 4) were administered intraperitoneally before the abdominal wall was closed. After 30 days, adhesions were classified by an independent surgeon.
Results:
Three animals died; one from group 3 and two from group 4. All control animals had substantial adhesions compared with unsubstantial adhesions observed in 11/15 in group 2 (P = 0.000), 11/14 in group 3 (P = 0.001), and 10/13 in group 4 (P = 0.000).
Conclusion:
Vitamin E, administered intraperitoneally, is as effective as HA/CBMC in preventing postoperative adhesions.
