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Updated: Jul 7, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with
Eduardo Hatschbach1, Fernando do Carmo Silva, Suzane Lílian Beier
1Faculty of Medicine of Botucatu, UNESP, São Paulo, Brazil.
Purpose:
To compare two propofol infusion techniques in bitches subjected to ovary histerectomy by estimating the efficiency of the propofol target-dose, evaluating the cardiorespiratory and hemogasimetric attributes, and the bispectral scale index (BIS) as well as the recovery period characteristics.
Methods:
Twenty anesthetized bitches were divided into two groups of 10 each (G1, G2). Animals of G1 were pre-treated with methotrimeprazine and anesthetized with target-controlled propofol infusion by means of a Harvard infusion pump combined to remifentanil through a syringe pump.
Results:
Bradycardia and light hypotension, hemogasimetric and respiratory stability besides a good myorelaxation, more evident during continuous infusion and good hypnosis.
Conclusions:
Dosis used in both techniques, after methotrimeprazine pre-treatment and combined to the opioid, were efficient for the surgery. The target-controlled anesthesia required a smaller anesthetic consumption (propofol) with faster recovery periods.
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