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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Expression of HOX C13 in odontogenic tumors]
Yan-song Hong1, Jie Wang, Jie Liu
1Department of Oral Pathology, College of Stomatology, China Medical University, Shenyang 110002, China.
Purpose:
To study the expression of HOXC13 mRNA in odontogenic tumors.
Methods:
HOXC13 mRNA was detected in 47 cases of ameloblastoma (AB), 3 cases of calcifying cystic odontogenic tumor (CCOT), 3 cases of ameloblastic fibroma (AF), 10 cases of keratocystic odontogenic tumor (KCOT) and 2 cases of calcifying epithelial odontogenic tumor (CEOT) by in situ hybridization, and 7 cases of normal oral mucosa were selected as control. SPSS10.0 software package was used for chi(2) test.
Results:
HOXC13 mRNA was positively expressed in all odontogenic epithelium except AF. The positive ratios were 97.9% in AB, 100% in CCOT, 100% in CEOT, 70.0% in KCOT epithelium and 42.9% in the normal oral mucosa. There was significant difference among AB, KCOT and normal mucosa (chi(2)=21.665, P<0.001).
Conclusions:
The genesis and development of odontogenic tumors are related to the high expression of HOXC13. The expression of HOXC13 mRNA in the odontogenic lesions has heterogeneity.
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