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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: Jul 7, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Ocular melanocytic neoplasia.

Michael Finn1, Sheryl Krohne, Jean Stiles

  • 1Purdue University.

Compendium (Yardley, PA)
|February 19, 2008
PubMed
Summary

Ocular melanocytic tumors in pets are uncommon but can be vision-threatening. Treatment and prognosis for these eyelid, conjunctival, limbal, and uveal tumors depend on species, location, and tumor type.

Area of Science:

  • Veterinary Ophthalmology
  • Comparative Pathology
  • Oncology

Background:

  • Ocular melanocytic tumors are rare in dogs and cats.
  • These tumors can range from benign to highly metastatic.
  • Even small ocular masses can threaten vision.

Purpose of the Study:

  • To review clinical presentation, biologic behavior, and treatment options for ocular melanocytic tumors in dogs and cats.
  • To discuss variations in prognosis and treatment based on tumor characteristics.
  • To cover tumors of the eyelids, conjunctiva, limbus, and uveal tract.

Main Methods:

  • Literature review of ocular melanocytic tumors in veterinary medicine.
  • Analysis of clinical data regarding presentation and behavior.
  • Synthesis of treatment strategies and prognostic factors.

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Related Experiment Videos

Last Updated: Jul 7, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

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Main Results:

  • Ocular melanocytic tumors present in various locations: eyelids, conjunctiva, limbus, and uvea.
  • Prognosis and treatment are highly dependent on tumor location, extent, histologic type, and species.
  • Some melanocytic tumors have significant metastatic potential, impacting overall patient outcome.

Conclusions:

  • Accurate diagnosis and understanding of tumor behavior are crucial for effective management.
  • Tailored treatment approaches are necessary for optimal outcomes in canine and feline ocular melanocytic tumors.
  • Further research may elucidate specific risk factors and enhance therapeutic strategies.