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Updated: Jul 7, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

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Antiangiogenic therapy and surgical practice.

A R John¹, S R Bramhall, M C Eggo

¹Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK. arj483@bham.ac.uk

The British Journal of Surgery

|February 19, 2008

Summary

Antiangiogenic therapy, including bevacizumab, offers a new treatment option. Despite initial challenges, ongoing research suggests a promising future for antiangiogenic drugs in clinical settings.

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Published on: November 23, 2014

Area of Science:

Oncology
Pharmacology
Biotechnology

Background:

Antiangiogenic therapy represents a significant advancement in cancer treatment.
Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF), exemplifies this new therapeutic approach.

Purpose of the Study:

To review the current status and future potential of antiangiogenic therapy.
To assess the clinical impact and expectations of antiangiogenic drugs.

Main Methods:

A comprehensive literature search was conducted.
Databases searched included PubMed, National Institute for Health and Clinical Excellence, and National Institutes of Health websites up to August 2007.

Main Results:

Many antiangiogenic drugs have not met initial expectations.
Bevacizumab has been introduced as a novel antiangiogenic agent.

Conclusions:

Antiangiogenic therapy is recognized as a potential fourth treatment modality.
Despite setbacks, continued research supports a future role for antiangiogenic therapy in clinical practice.