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Synthesis and cytotoxic evaluation of some cribrostatin-ecteinascidin analogues
Benjamin J D Wright1, Collin Chan, Samuel J Danishefsky
1Department of Chemistry, Columbia University, New york, NY 10027, USA.
Journal of Natural Products
|February 19, 2008
Abstract:
Analogues of cribrostatin IV ( 1) and the potent antineoplastic agent ecteinascidin 743 ( 2) have been synthesized. The cytotoxic activity of these compounds ( 5, 14, 20) has been determined, and the cyanoamine-cribrostatin analogue ( 14) exhibits a 20-fold improvement with regard to the natural product 1.
