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Updated: Jul 7, 2026
Monitoring Protein Adsorption with Solid-state Nanopores
Published on: December 2, 2011
Simultaneous investigation of the influence of topography and charge on protein adsorption using artificial
E Macarena Blanco1, Michael A Horton, Patrick Mesquida
1London Centre for Nanotechnology and Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, United Kingdom.
Abstract:
The combined influence of surface topography and charge of a polymer surface on the adsorption of the protein avidin has been investigated. Atomic force microscopy contact mode imaging and charge writing were used to create defined topographical roughness and electrostatic charge patterns on the surface of polystyrene. Increased avidin adsorption was found on nanometer-size topographical patterns, but the adsorption remained unaffected by electrostatic patterns.
