Effect of senescence on macrophage polarization and angiogenesis
1Department of Ophthalmology and Visual Sciences, Washington University, St. Louis School of Medicine, St. Louis, Missouri 63110, USA.
Rejuvenation Research
|February 19, 2008
Abstract:
There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.

