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Updated: Jul 7, 2026
11:30
A Quantitative Evaluation of Cell Migration by the Phagokinetic Track Motility Assay
Published on: December 4, 2012
Autocrine motility factor receptor: a clinical review
Connie G Chiu1, Pascal St-Pierre, Ivan R Nabi
1St Paul's Hospital, Department of Surgery, University of British Columbia, C303-1081 Burrard Street, Vancouver, BC, Canada. c.chiu@interchange.ubc.ca
Expert Review of Anticancer Therapy
|February 19, 2008
Summary
Autocrine motility factor receptor (AMFR) is linked to advanced cancer stages and reduced survival across multiple cancer types. Targeting AMFR may offer a new therapeutic strategy for improving patient outcomes in oncology.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Metastasis is a key determinant of cancer patient mortality.
- Autocrine motility factor receptor (AMFR) is a cell surface receptor with implications in cancer progression.
- AMFR's role in cellular adhesion, proliferation, and motility is activated by its ligand.
Purpose of the Study:
- To review the correlation between AMFR expression and cancer progression.
- To evaluate AMFR as a prognostic biomarker in various human cancers.
- To highlight the potential of AMFR as a therapeutic target.
Main Methods:
- Literature review of studies investigating AMFR expression in human cancers.
- Analysis of associations between AMFR levels and clinicopathologic parameters.
- Evaluation of AMFR's correlation with tumor stage and patient survival.
Main Results:
- Increased AMFR expression is significantly correlated with advanced tumor stage in lung, esophageal, stomach, colon, rectal, liver, and skin cancers.
- AMFR upregulation is associated with decreased patient survival and serves as an independent predictor of poor prognosis.
- AMFR expression correlates with other parameters implicated in cancer progression.
Conclusions:
- AMFR is upregulated in numerous human cancers and linked to adverse outcomes.
- AMFR represents a promising biomarker for cancer prognosis.
- Further research into AMFR's molecular regulation is crucial for developing targeted anticancer therapies.
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