Related Experiment Video
Updated: Jul 7, 2026
Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
Published on: August 13, 2010
Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B
Shigefumi Okamoto1, Yutaka Terao, Yasuharu Tamura
1Laboratory of Virology and Vaccinology, National Institute of Biomedical Innovation, Ibaraki-Osaka, Japan.
Abstract:
Group A Streptococcus (GAS) produces several immunopotent proteins such as the immunoglobulin-binding protein 35 (Sib35) family, known to be an immunoglobulin G-degrading enzyme of GAS and a CD16-binding protein of GAS, Mac-1-like protein/IdeS. In this study, Sib35 activated mouse B cells and induced the proliferation of B lymphocytes, while it also bound directly to B cells, which enhanced the expression of MHC class II and B7-2. Furthermore, Sib35 induced the differentiation of B cells to immunoglobulin-producing plasma cells and B cell line proliferation. These results suggest that Sib35 functions as a streptococcal mitogen of mouse B cells.
More Related Videos
06:15Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
Published on: September 7, 2018
09:11Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection
Published on: July 16, 2019