Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Encoding problem-solving strategies in prefrontal cortex: activity during strategic errors.

Aldo Genovesio1, Satoshi Tsujimoto, Steven P Wise

  • 1Laboratory of Systems Neuroscience, National Institute of Mental Health, Building 49, Room B1EE17, 49 Convent Drive, MSC 4401, Bethesda, MD 20892-4401 USA. genovesa@mail.nih.gov

The European Journal of Neuroscience
|February 19, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Relative Authorship Index: A New Metric for Evaluating Individual Contribution in Scientific Research.

The European journal of neuroscience·2026
Same author

History bias and its perturbation of the stimulus representation in the macaque prefrontal cortex.

The Journal of physiology·2026
Same author

Efficiency and robustness in three cortical areas: frontal pole cortex, dorsolateral prefrontal cortex and orbitofrontal cortex.

Neuroscience·2025
Same author

Endogenous and exogenous attentional interplay through mixed prefrontal cortex resources.

Current biology : CB·2025
Same author

Out of the single-neuron straitjacket: Neurons within assemblies change selectivity and their reconfiguration underlies dynamic coding.

The Journal of physiology·2025
Same author

Cell types implement multiple coding schemes in distinct prefrontal cortex areas during goal-directed behavior.

Progress in neurobiology·2025
Same journal

Training in the Categorization of Aerial and Terrestrial Scenes Differentially Impacts Scene-Selective and Nonscene-Selective Regions in Occipitotemporal Cortex.

The European journal of neuroscience·2026
Same journal

Superficial Ventral Premotor Pathways to Primary Motor Cortex Shape the Temporal Coordination of Precision Grasping.

The European journal of neuroscience·2026
Same journal

Quantifying the Influence of Lexical Surprisal on Acoustic Speech Encoding While Controlling for Within-Speaker Variability.

The European journal of neuroscience·2026
Same journal

Profiles of Women in Science: Seung-Hee Lee, Associate Professor at the Korea Advanced Institute of Science and Technology and Associate Director of the Institute for Basic Science, Daejeon, Republic of Korea.

The European journal of neuroscience·2026
Same journal

Impact of Voluntary Alcohol Consumption on Corticostriatal Plasticity in Rats.

The European journal of neuroscience·2026
Same journal

The Relevance of a Philosophical Toolkit to Advance Neuroscience.

The European journal of neuroscience·2026
See all related articles

Neurons in the primate prefrontal cortex (PF) encode chosen strategies. Activity during cue presentation was weaker on error trials, suggesting a role in errors, while later activity may monitor performance.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • The primate prefrontal cortex (PF) is crucial for goal selection and strategy implementation.
  • Understanding PF neuronal mechanisms is key to deciphering decision-making processes.

Purpose of the Study:

  • To investigate how primate prefrontal cortex (PF) neurons encode abstract response strategies during goal-directed behavior.
  • To examine the relationship between neuronal activity, strategy use, and task performance, including errors.

Main Methods:

  • Neuronal recordings from the primate prefrontal cortex (PF) in monkeys performing a spatial goal selection task.
  • Analysis of neural activity during 'repeat' and 'change' trials, distinguishing between correct and error trials.

Main Results:

Related Experiment Videos

  • Many PF neurons encoded one of two strategies (Repeat-stay or Change-shift) during correct trials.
  • Strategy coding was weak or absent during the cue period of error trials.
  • Strategy coding was present and reflected the actual strategy used (correct or incorrect) later in the trial, prior to feedback.

Conclusions:

  • Weak cue-period strategy signals in the PF may contribute to errors in strategy selection.
  • Post-feedback activity in the PF might play a role in monitoring task performance and strategy adherence.