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[The effect of sufentanil on acute lung injury in rabbits]
Cheng-Ming Zhang1, Jin-Ling Yu, Yan Zhang
1Department of Anesthesiology, Affiliated Hospital of Weifang Medical College, Weifang 261042, Shandong, China.
Objective:
To study the effect of sufentanil on acute lung injury induced by hemorrhagic shock in rabbits.
Methods:
Fifty-four healthy rabbits were randomly divided into three groups: control group,with only incision of trachea; model group, hemorrhagic shock was produced according to modified Wiggers' method; sufentanil group, intravenous injection of sufentanil at 0.02 microg x kg(-1) x h(-1) after hemorrhagic shock. To all the rabbits, intravenous Ringer lactate solution was given in an amount of 5 ml x kg(-1) x h(-1). Mean arterial pressure (MAP), heart rate (HR) and plasma tumor necrosis factor-alpha (TNF-alpha) were determined before shock, 1, 2, 3 and 4 hours after resuscitation. Malondialdehyde (MDA) and water content of lungs were measured 1, 2 and 4 hours after resuscitation.
Results:
At same time points, MAP and HR in sufentanil group and model group were lower than that in control group (P<0.05) but contents of TNF-alpha in serum, MDA in lung tissue and water content of lungs were elevated gradually. The degree of decrease or increase was less obvious in sufentanil than in model group (P<0.05 or P<0.01).
Conclusion:
Hemorrhagic shock could increase arterial plasma TNF-alpha content with lung injury. Sufentanil could alleviate acute lung injury induced by hemorrhagic shock in rabbits.
