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[Prevalence of undetected chronic kidney disease in dyslipidemic population treated in primary care. LIPICAP study]
José L Llisterri Caro1, José L Gorriz Teruel, Francisco J Alonso Moreno
1Centro de Salud Joaquín Benlloch, Valencia, España. jllisterric@medynet.com
Insights
Undetected chronic kidney disease (CKD) affects nearly 20% of dyslipidemic patients in Spanish primary care. This prevalence is higher in women, older individuals, and those with lower body mass index, highlighting a significant public health concern.
Area of Science:
- Nephrology
- Cardiology
- Primary Care Medicine
Context:
- Chronic kidney disease (CKD) is a growing public health concern with limited data on its prevalence in primary care settings.
- Dyslipidemia is a common condition managed in primary care, often coexisting with other chronic diseases.
- Assessing CKD in dyslipidemic patients is crucial for cardiovascular risk stratification and management.
Purpose:
- To determine the prevalence of undetected CKD in a dyslipidemic population managed in primary care.
- To utilize the Cockcroft-Gault equation corrected for surface area for estimating creatinine clearance and diagnosing CKD.
- To identify sociodemographic and clinical factors associated with CKD in this patient group.
Summary:
- A cross-sectional study of 5,990 dyslipidemic patients in primary care found a CKD prevalence of 16.2% using the Cockcroft-Gault equation.
- CKD was significantly more prevalent in women (22.7%) than men (9.8%).
- Factors associated with higher CKD probability included female gender, older age, and lower body mass index.
Impact:
- The findings suggest that a substantial proportion of dyslipidemic patients in primary care have undiagnosed CKD, necessitating targeted screening.
- Early detection of CKD in this population can lead to timely interventions, potentially reducing cardiovascular complications and disease progression.
- This study underscores the importance of routine renal function assessment in patients with dyslipidemia within primary care settings.
Background And Objective:
Information about the prevalence of chronic kidney disease (CKD) in population treated in primary care (PC) is scarce. The aim of this study was to determine undetected CKD prevalence in dyslipidemic population measuring creatinine clearance according to the Cockcroft-Gault equation corrected for surface area.
Patients And Method:
Cross-sectional study including patients with diagnosis of dyslipidemia selected by consecutive sampling in PC. CKD was diagnosed when the glomerular filtration rate (GFR) was < 60 ml/min/1.73 m2. We assessed sociodemographic and clinical data, cardiovascular risk factors, coronary disease risk categories, dyslipidemia characteristics, functional CKD stage, and pharmacological treatments.
Results:
The sample included 5,990 patients (50.2% women). The mean (standard deviation) age was 60.9 (11.1) years. The main reason for iclusion was hypercholesterolemia (65%), followed by mixed hyperlipidemia (26.4%), low high density lipoproteins (HDL)-cholesterol (4.9%) and hypertrigliceridemia (3.7%). According to the Cockcroft-Gault equation, CKD prevalence was 16.2% (95% confidence interval, 15.3-17.1) and it was significantly higher in women (22.7%) than in men (9.8%) (p < 0.0001). Patients with CKD were older compared with patients with normal GFR, and had higher systolic blood pressure, glucose and HDL-cholesterol (p < 0.001), as well as lower levels of total cholesterol, low density lipoproteins-cholesterol, and triglycerides (p < 0.01). The probability of presenting CKD was related to female gender, age, and lower body mass index.
Conclusions:
The LIPICAP study results indicate that almost 20% of PC dyslipidemic patients in Spain present undetected CKD when the GFR is measured according to the Cockcroft-Gault equation corrected for surface area.
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