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Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
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Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
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Oxidative stress in perinatal asphyxia.

Ashok Kumar1, Satya Venkata Kalyan Ramakrishna, Sriparna Basu

  • 1Division of Neonatology, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. ashokkumar_bhu@hotmail.com

Pediatric Neurology
|February 19, 2008
PubMed
Summary
This summary is machine-generated.

Perinatal asphyxia increases oxidative stress in newborns, evidenced by higher malondialdehyde levels. Despite elevated antioxidant enzymes, neonates experience significant tissue injury from oxygen free radicals.

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A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation

Published on: January 13, 2023

Area of Science:

  • Biomedical Science
  • Neonatal Research
  • Oxidative Stress

Background:

  • Perinatal asphyxia is a significant cause of neonatal morbidity and mortality.
  • Oxygen free radicals are implicated in tissue injury during hypoxic-ischemic events.
  • Understanding oxidative stress markers is crucial for managing perinatal asphyxia.

Purpose of the Study:

  • To investigate the role of oxidative stress in perinatal asphyxia.
  • To measure levels of malondialdehyde and antioxidant enzymes in newborns with and without perinatal asphyxia.
  • To correlate oxidative stress markers with the severity of hypoxic-ischemic encephalopathy and outcomes.

Main Methods:

  • Plasma and cerebrospinal fluid malondialdehyde levels were measured.
  • Plasma levels of glutathione peroxidase, catalase, and superoxide dismutase were assessed.
  • A cohort of 50 term newborns with perinatal asphyxia and 8 controls were studied, excluding neonates with sepsis, congenital malformations, or hemolytic disease.

Main Results:

  • Newborns with perinatal asphyxia showed significantly higher plasma and cerebrospinal fluid malondialdehyde levels.
  • Increased levels of plasma antioxidant enzymes (glutathione peroxidase, catalase, superoxide dismutase) were observed in asphyxiated neonates.
  • Malondialdehyde and catalase levels correlated with the severity of hypoxic-ischemic encephalopathy and mortality.

Conclusions:

  • Perinatal asphyxia leads to increased oxidative stress, despite elevated antioxidant enzyme activity.
  • Elevated malondialdehyde levels indicate significant tissue injury mediated by oxygen free radicals.
  • These findings highlight the critical role of oxidative stress in the pathophysiology of perinatal asphyxia.