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Updated: Jul 7, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Therapeutic erythrocytapheresis: technical aspects and clinical applications]
1Service d'hémaphérèse et d'autotransfusion, hôpital de la Conception, 13385 Marseille cedex 05, France. pascale.poullin@ap-hm.fr
Purpose:
Therapeutic erythrocytapheresis is a selective red cell-depletion aphaeresis technique.
Current Knowledge And Key Point:
Using a discontinuous or continuous flow blood cell separator, the technique safely allows quickly and automatically collecting a large volume of red cells. The main obstacle of implementation is a poor peripheral venous access. The procedure is well-tolerated. Polycythemia vera, hereditary hemochromatosis, complicated sickle-cell-disease and retinal venous occlusion are the main clinical applications.
Prospect And Project:
Therapeutic erythrocytapheresis is a more modern and more effective method than the classic patient-bleeding. It has to be preferred in the early treatment of patients with polycythemia vera and hereditary hemochromatosis.
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