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Related Experiment Videos

Oral squamous cell carcinoma margin discrepancy after resection and pathologic processing.

Allen Cheng1, Darren Cox, Brian L Schmidt

  • 1Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143-0440, USA.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|February 19, 2008
PubMed
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Margin discrepancies in oral squamous cell carcinoma (SCC) resections are significant, especially for tumors on the buccal mucosa, retromolar trigone, and mandibular alveolar ridge. Late-stage tumors also exhibit greater discrepancies, impacting treatment decisions.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Oral Surgery

Background:

  • Achieving adequate surgical margins is crucial for oral squamous cell carcinoma (SCC) resection to prevent recurrence and guide adjuvant therapy.
  • A significant challenge in oral SCC surgery is the discrepancy between intraoperative margin assessment and final histopathological evaluation.
  • Understanding this discrepancy is vital for optimizing surgical planning and patient outcomes.

Purpose of the Study:

  • To quantify and compare margin discrepancies in oral SCC resections.
  • To analyze how tumor location and clinical staging influence margin discrepancy.
  • To provide data for refining surgical margin guidelines in oral SCC.

Main Methods:

  • Retrospective analysis of 41 patients undergoing primary oral SCC resection with a 1 cm planned margin.

Related Experiment Videos

  • Comparison of intraoperative margin measurements with post-processing histopathological margin measurements.
  • Grouping and statistical analysis of margin discrepancies by tumor location (buccal mucosa, alveolar ridges, palate, oral tongue) and T-stage (T1/T2 vs. T3/T4).

    • Main Results:

    • A statistically significant mean margin discrepancy of 59.02% was observed across all patients.
    • Tumor location significantly impacted discrepancy: Group 1 (buccal mucosa, mandibular alveolar ridge, retromolar trigone) showed 71.90% mean discrepancy, Group 2 (maxillary alveolar ridge, palate) showed 53.33%, and Group 3 (oral tongue) showed 42.14%.
    • Advanced T-stage tumors (T3/T4) exhibited significantly greater margin discrepancies (75.00%) compared to early-stage tumors (T1/T2) (51.48%).

    Conclusions:

    • Significant discrepancies exist between planned and histopathological margins in oral SCC resections.
    • Tumors in specific locations (buccal mucosa, retromolar trigone, mandibular alveolar ridge) and later stages (T3/T4) are associated with larger margin discrepancies.
    • Considering tumor site and stage during margin assessment may improve the adequacy of oral SCC resections.