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Published on: August 15, 2017
A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus
Tiina Immonen1, Anniina Alakuijala, Marjo Hytönen
1Department of Medical Biochemistry and Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, P.O.Box 63, FI-00014 University of Helsinki, Finland. tiina.immonen@helsinki.fi
Abstract:
The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor.
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