Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Persistent platelet activation by passivated grafts.

R K Ito1, C M Brophy, M A Contreras

  • 1New England Deaconess Hospital, Harvard Surgical Service, Boston, MA 02215.

Journal of Vascular Surgery
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral i.v. analysis (PIVA) of venous waveforms for volume assessment in patients undergoing haemodialysis.

British journal of anaesthesia·2017
Same author

Genetic relationships among American donkey populations: insights into the process of colonization.

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie·2015
Same author

Fiber-fed time-resolved photoluminescence for reduced process feedback time on thin-film photovoltaics.

The Review of scientific instruments·2015
Same author

[Syphilis; problems in diagnosis & therapy].

Revista medica dominicana·2014
Same author

Histology of the internal inguinal ring: it is really a novelty?

Hernia : the journal of hernias and abdominal wall surgery·2010
Same author

Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: results from the electronic Schizophrenia Treatment Adherence Registry (e-STAR).

European psychiatry : the journal of the Association of European Psychiatrists·2009
Same journal

Procedural outcomes and follow-up of endovascular treatment for extracranial carotid artery aneurysms; a systematic review.

Journal of vascular surgery·2026
Same journal

Impact of Insurance Status on Urgency of Presentation and Perioperative Outcomes Following Endovascular Repair of Abdominal Aortic Aneurysms: A Vascular Quality Initiative Analysis.

Journal of vascular surgery·2026
Same journal

Large language models routinely overcode peripheral endovascular procedures relative to professional coders.

Journal of vascular surgery·2026
Same journal

Comparison of Deep and Non-Deep Hypothermia in Thoracic and Thoracoabdominal Aortic Surgery: A Systematic Review and Meta-Analysis.

Journal of vascular surgery·2026
Same journal

Horner Syndrome Secondary to Giant Shamblin Type III Carotid Body Tumor.

Journal of vascular surgery·2026
Same journal

Three-Year Outcomes of Supera Interwoven Nitinol Stents Versus Eluvia Drug-Eluting Stents in Severely Calcified Femoropopliteal Lesions.

Journal of vascular surgery·2026
See all related articles

Vascular grafts in dogs show persistent platelet activation on their surface, even after healing. This study reveals significant platelet-graft interactions impacting systemic platelet counts and responses over eight months.

Area of Science:

  • Biomedical Engineering
  • Vascular Surgery
  • Hematology

Background:

  • Vascular grafts heal by forming a pseudointima, but only near connections.
  • The graft's mid-surface pseudointima may cause ongoing platelet activation.
  • Understanding this interaction is crucial for improving graft outcomes.

Purpose of the Study:

  • To investigate how a maturing vascular graft surface affects platelet activation.
  • To analyze platelet behavior and systemic effects in a canine model.

Main Methods:

  • Implanted Dacron vascular grafts in nine dogs for eight months.
  • Collected blood samples at multiple time points for platelet analysis.
  • Measured platelet counts, aggregation, and adenosine triphosphate release using specific agonists.

Related Experiment Videos

Main Results:

  • Systemic platelet counts decreased by 50% in graft dogs, persisting for eight months.
  • Platelets released less adenosine triphosphate (ATP) distally versus proximally.
  • Graft animals showed reduced platelet aggregation response to collagen and adenosine diphosphate (ADP) compared to sham controls.

Conclusions:

  • Mature vascular graft pseudointima is associated with significant platelet-graft interactions.
  • These interactions lead to reduced systemic platelet counts and altered platelet function.
  • Further research is needed to mitigate these persistent platelet responses.