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[A case of dihydropyrimidine dehydrogenase (DPD) deficiency with severe side effects from UFT/Uzel administration]

Kyohei Kai1, Yoshikatsu Endo, Kazuhiro Yoshida

  • 1Dept. of Surgery, Himeji Red Cross Hospital.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 19, 2008
PubMed

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Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
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