Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Decade of Innovation: A 10-year Institutional Review of Advancements in Vascularized Composite Allotransplantation.

Plastic and reconstructive surgery. Global open·2026
Same author

Epidemiological and Surgical Insights Into Concomitant Ocular and Craniofacial Trauma and the Implications for Combined Face and Whole-eye Transplantation.

Plastic and reconstructive surgery. Global open·2026
Same author

The State of Posttransplant Malignancies in Vascularized Composite Allotransplantation.

Plastic and reconstructive surgery. Global open·2026
Same author

Together Everyone Achieves More: A Team-based Analysis of the First Successful Face and Bilateral Hand Transplant.

Plastic and reconstructive surgery. Global open·2026
Same author

A Systematic Review of the Clinical Application of Topical Tacrolimus in Vascularized Composite Allotransplantation.

Plastic and reconstructive surgery. Global open·2026
Same author

Rituximab-based Induction in Vascularized Composite Allotransplantation: Prolonged Rejection-free Survival and the Role of Donor-specific Antibodies.

Plastic and reconstructive surgery. Global open·2026

Related Experiment Video

Updated: Jul 7, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

Recurrent abdominal laxity following interpositional human acellular dermal matrix.

Rachel Bluebond-Langner1, Emily S Keifa, Suhail Mithani

  • 1R. Adams Cowley Shock Trauma Center, Baltimore, Maryland, USA.

Annals of Plastic Surgery
|February 19, 2008
PubMed
Summary

Using Alloderm alone for complex abdominal hernia repair led to recurrent laxity in 7 patients within a year. These cases required secondary procedures due to severe Alloderm attenuation, highlighting the need for mesh reinforcement.

Related Experiment Videos

Last Updated: Jul 7, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

Area of Science:

  • Abdominal surgery
  • Hernia repair
  • Biomaterials in surgery

Background:

  • Large complex abdominal hernias with loss of domain necessitate component separation and interpositional materials.
  • Previous algorithms incorporated Alloderm (biologic material) with synthetic mesh overlay for complex hernia repair.
  • The efficacy of Alloderm alone as an interpositional material in such cases requires further investigation.

Purpose of the Study:

  • To report on recurrent abdominal wall laxity in patients repaired with interpositional Alloderm alone.
  • To evaluate the long-term outcomes of using Alloderm without synthetic mesh overlay in complex hernia repair.
  • To identify potential complications and necessary interventions following this surgical approach.

Main Methods:

  • Retrospective review of patients undergoing massive ventral hernia repair.
  • Identification of patients who developed abdominal wall laxity after component separation with interpositional Alloderm.
  • Analysis of surgical findings, including the condition of the Alloderm graft, and subsequent treatments.

Main Results:

  • Seven patients presented with abdominal wall laxity within 12 months post-repair.
  • Severe attenuation of the Alloderm graft was observed during re-exploration in all cases.
  • All patients required a secondary procedure, involving excision of the attenuated Alloderm and placement of a prolene mesh onlay.

Conclusions:

  • Interpositional Alloderm alone may lead to significant abdominal wall laxity and failure in complex hernia repair.
  • Severe attenuation of Alloderm necessitates secondary surgical intervention, often involving synthetic mesh.
  • The use of synthetic mesh overlay in conjunction with biologic grafts like Alloderm may be crucial for durable complex hernia repair.