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Coronary artery disease among asymptomatic diabetic and nondiabetic patients undergoing coronary computed tomography

Abdel-Rauf Zeina1, Majed Odeh, Uri Rosenschein

  • 1Department of Radiology and MAR Imaging Institute, Bnai Zion Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. raufzeina3@hotmail.com

Coronary Artery Disease
|February 19, 2008
PubMed

Insights

Asymptomatic diabetic patients show a high prevalence of coronary artery disease (CAD), with 93% affected. Coronary computed tomography angiography (CCTA) can identify high-risk individuals needing further evaluation for subclinical ischemia.

Area of Science:

  • Cardiology
  • Diabetology
  • Medical Imaging

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality in diabetic patients.
  • The prevalence of CAD in asymptomatic individuals with diabetes is not well-established.

Purpose of the Study:

  • To determine the prevalence and severity of CAD in asymptomatic diabetic versus nondiabetic patients.
  • To analyze plaque composition using coronary computed tomography angiography (CCTA).

Main Methods:

  • 328 asymptomatic patients with cardiac risk factors were evaluated.
  • 42 diabetic and 286 nondiabetic patients underwent CCTA and were matched for age, sex, and risk factors.
  • CAD was defined as obstructive or nonobstructive coronary atherosclerosis.

Main Results:

  • CAD prevalence was significantly higher in diabetic patients (93%) compared to nondiabetic patients (73%).
  • Obstructive CAD was more frequent in diabetic individuals (29% vs. 6.6%).
  • Diabetic patients exhibited more affected coronary segments and higher Agatston scores.

Conclusions:

  • A high prevalence of CAD exists in asymptomatic diabetic patients, regardless of lesion severity.
  • CCTA is a valuable tool for identifying high-risk diabetic patients who may benefit from further assessment for subclinical ischemia.
Abstract

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