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Related Concept Videos

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Related Experiment Video

Updated: Jul 7, 2026

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
08:42

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

Hypertrophic osteoarthropathy: a palindrome with a pathogenic connotation.

Manuel Martinez-Lavin1, Angélica Vargas, Miguel Rivera-Viñas

  • 1Rheumatology Department, National Institute of Cardiology, Mexico. mmlavin@infosel.net.mx

Current Opinion in Rheumatology
|February 19, 2008
PubMed
Summary

Hypertrophic osteoarthropathy is a palindromic syndrome. Abnormal vascular endothelial growth factor (VEGF) may drive its development, and bisphosphonates may offer symptomatic relief.

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Last Updated: Jul 7, 2026

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
08:42

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

Area of Science:

  • Rheumatology
  • Endocrinology
  • Pathology

Background:

  • Hypertrophic osteoarthropathy (HO) is a rare condition characterized by digital clubbing, arthritis, and subperiosteal new bone formation.
  • HO can be primary or secondary to various underlying conditions, including lung cancer, congenital heart disease, and inflammatory bowel disease.

Purpose of the Study:

  • To review recent advances in understanding the pathogenesis of hypertrophic osteoarthropathy.
  • To describe a novel palindromic pattern observed in HO and its potential pathogenic implications.
  • To evaluate the role of bisphosphonates in managing HO symptoms.

Main Methods:

  • Literature review of studies on hypertrophic osteoarthropathy pathogenesis, clinical features, and treatment.
  • Analysis of case reports and clinical studies investigating the palindromic nature of HO.
  • Review of evidence regarding vascular endothelial growth factor (VEGF) in HO and the efficacy of bisphosphonates.

Main Results:

  • A palindromic pattern in HO is identified, where patients develop secondary causes of HO years after primary HO onset.
  • Shared clinical features and abnormal vascular endothelial growth factor (VEGF) production link primary HO, POEMS syndrome, Crohn's disease, and myelofibrosis.
  • VEGF's role in pathogenesis is supported by abnormal expression in HO and its known effects on other associated conditions.

Conclusions:

  • Hypertrophic osteoarthropathy exhibits a palindromic characteristic, potentially explained by anomalous VEGF expression.
  • Bisphosphonates show promise for symptomatic treatment of painful osteoarthropathy in HO.