Related Experiment Video
Updated: Jul 7, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Taurine attenuates aminoglycoside ototoxicity by inhibiting inducible nitric oxide synthase expression in the cochlea
Hai-Ying Liu1, Fang-Lu Chi, Wen-Yuan Gao
1Department of Physiology, the Second Military Medical University, Shanghai, PR China.
Abstract:
This study explored the potential protective role of taurine against aminoglycoside ototoxicity and the involvement of inducible nitric oxide synthase (iNOS) in the process. Guinea pigs, which received a single intravenous administration of gentamycin (100 mg/kg) followed by one large dose of furosemide (90 mg/kg, intravenously) were used as subjects. A rapid and profound hearing loss was seen in these animals 3-day posttreatment with iNOS expression upregulated in the cochlea. However, pretreatment with taurine prevented the hearing damage with decreased iNOS expression, similar to the effect of aminoguanidine, a selective inhibitor of iNOS. These findings suggest that taurine provides protection against the acute gentamycin/furosemide ototoxicity possibly by downregulating iNOS expression in the cochlea.
More Related Videos
12:21The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
Published on: November 26, 2015
09:06Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
Published on: January 9, 2019
Related Concept Videos
Inhibitors of Bacterial Protein Synthesis
Drugs Affecting Neurotransmitter Synthesis
Transcription Attenuation in Prokaryotes
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
The Cochlea
Estimation of k and VD of Aminoglycosides