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[Antibiotic prophylaxis with ceftazidime in pediatric surgery]
A Inserra1, P Serventi, G Ciprandi
1Istituto di Ricerca Scientifica, Divisione di Chirurgia Pediatrica, Ospedale del Bambin Gesù Roma.
Insights
Ceftazidime demonstrates excellent tolerability and effectiveness for surgical prophylaxis in pediatric patients. This antibiotic showed rapid results with minimal complications, even in high-risk "dirty surgery" cases.
Area of Science:
- Pediatric Surgery
- Infectious Diseases
- Pharmacology
Background:
- Surgical site infections are a significant concern in pediatric surgery.
- Effective antibiotic prophylaxis is crucial for preventing postoperative complications.
Purpose of the Study:
- To evaluate the efficacy and safety of Ceftazidime for surgical prophylaxis in children.
- To assess the tolerability and effectiveness of Ceftazidime in pediatric surgical patients.
Main Methods:
- A study involving 50 pediatric patients undergoing surgery.
- Ceftazidime administered at 100 mg/kg in three doses: pre-surgery, 6 hours post-surgery, and 12 hours post-surgery.
- Clinical and bacterial outcomes were monitored.
Main Results:
- No adverse side effects were reported, and treatment discontinuation was not necessary.
- Excellent tolerability and rapid clinical and bacterial effectiveness were observed.
- Complications occurred in 6% of patients (wound infiltration, Douglas abscess), primarily in "dirty surgery" cases (18.7%), which is lower than literature values.
Conclusions:
- Ceftazidime is a well-tolerated and effective antibiotic for surgical prophylaxis in pediatric patients.
- The drug shows rapid effectiveness and a favorable safety profile, even in complex surgical scenarios.
- The low complication rate in high-risk surgeries suggests Ceftazidime's utility in challenging pediatric surgical cases.
Abstract:
The authors report their experience with Ceftazidime in surgical prophylaxis in childhood. 50 patients have been treated, suffering from surgical diseases, with 100 mg/kg of Ceftazidime in 3 doses (1 before, 1 after 6 hrs and 1 after 12 hrs from surgery). No side effects were observed and in no case was it necessary to discontinue treatment. Both bacterial and clinical results indicate good tolerability and very rapid effectiveness of the drug. Complications were present in 3 cases (6%) (in 2 cases wound infiltration and in 1 case a Douglas abscess) but no modification in treatment was necessary. All complications were present in so-called "dirty surgery" with a relative percentage of 18.7, that is far below values reported in the literature for this kind of surgery.