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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...

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Related Experiment Video

Updated: Jul 7, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Biologic treatments for systemic rheumatic diseases.

Y Shirota¹, G G Illei, N P Nikolov

¹Sjögren's Syndrome Clinic, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

|February 20, 2008

Summary

Biologic therapies have revolutionized rheumatology, offering new treatments for rheumatic diseases and impacting oral health. This review explores these advancements and their effects on dental complications associated with conditions like Sjögren

Related Experiment Videos

Last Updated: Jul 7, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Area of Science:

Rheumatology and Oral Health

Background:

Rheumatologic disorders, such as Sjögren's syndrome, frequently cause dental complications.
Oral diseases can sometimes trigger or exacerbate connective tissue diseases.

Purpose of the Study:

To review the current state of biologic therapies in rheumatology.
To discuss the implications of these therapies on oral health and disease.

Main Methods:

Literature review of advancements in rheumatology and biologic agents.
Analysis of the impact of these treatments on oral health outcomes.

Main Results:

Disease-modifying anti-rheumatic drugs have transformed rheumatologic treatment over 30 years.
New targeted biologic agents have emerged based on understanding inflammation and autoimmunity.

Conclusions:

Biologic therapies represent a significant advancement in managing rheumatic diseases.
Understanding the interplay between rheumatology treatments and oral health is crucial for comprehensive patient care.