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Systemic contact dermatitis from pseudoephedrine.

R R Tomb1, J P Lepoittevin, F Espinassouze

  • 1Clinique Dermatologique, Hôpital Civil, Strasbourg, France.

Contact Dermatitis
|February 1, 1991
PubMed
Summary
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Systemic contact dermatitis and eczema can be triggered by oral decongestants like pseudoephedrine hydrochloride and norephedrine hydrochloride. Patch testing confirmed sensitivity to ephedrine and pseudoephedrine in a rhinitis patient.

Area of Science:

  • Pharmacology
  • Dermatology
  • Allergy

Background:

  • Rhinitis is a common condition often treated with oral medications.
  • Systemic contact dermatitis is a rare but serious adverse reaction to ingested substances.

Observation:

  • A patient with rhinitis experienced adverse skin reactions after initiating oral Rhinalair (pseudoephedrine hydrochloride).
  • A subsequent oral treatment, Rinutan (norephedrine hydrochloride), led to a more severe generalized eczema.

Findings:

  • Patch testing revealed strong positive reactions to ephedrine and pseudoephedrine.
  • Reactions were slightly positive to phenylephrine and negative to epinephrine.
  • Norephedrine was not included in the patch testing protocol.

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Implications:

  • These findings suggest potential cross-reactivity among sympathomimetic amines used in cold and allergy medications.
  • Clinicians should consider pseudoephedrine and related compounds as potential triggers for systemic contact dermatitis and eczema.
  • Further investigation into norephedrine's role and cross-reactivity patterns is warranted.