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Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation
Published on: September 29, 2019
The calcium-binding protein S100P in normal and malignant human tissues
Seppo Parkkila1, Pei-Wen Pan, Aoife Ward
1Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland. seppo.parkkila@uta.fi
BMC Clinical Pathology
|February 20, 2008
Summary
S100P calcium-binding protein is widely expressed in normal human tissues and various cancers. Its high prevalence in tumors like gastric cancer suggests potential for diagnostic and therapeutic applications.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- S100P (calcium-binding protein) is overexpressed in many cancers, indicating potential as a tumor biomarker.
- Limited knowledge exists regarding S100P's normal expression patterns and physiological functions.
Purpose of the Study:
- To investigate the expression profile of S100P in normal human tissues.
- To analyze S100P protein expression in a diverse range of human carcinomas.
Main Methods:
- Quantitative reverse transcription polymerase chain reaction (qRT-PCR) for S100P mRNA.
- Immunohistochemistry to assess S100P protein levels in normal tissues and tumors.
- Utilized a novel anti-S100P monoclonal antibody for tumor specimen analysis.
Main Results:
- Highest S100P mRNA levels detected in normal placenta and esophagus; moderate levels in stomach, duodenum, large intestine, prostate, and leukocytes.
- S100P protein expression was highest in normal placenta and stomach.
- S100P protein was detected in all tumor types studied, with the highest prevalence observed in gastric carcinomas.
Conclusions:
- S100P exhibits broad expression in both normal and malignant human tissues.
- Elevated S100P expression in certain cancers highlights its potential as a target for future diagnostic and therapeutic strategies.
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