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Related Experiment Video

Updated: Jul 7, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Free radicals and senescence.

Teng Lu¹, Toren Finkel

¹Translational Medicine Branch, NHLBI, NIH, Building 10/CRC 5-3330, Bethesda, MD 20892, USA.

Experimental Cell Research

|February 20, 2008

Summary

A rise in intracellular reactive oxygen species (ROS) is linked to cellular senescence. This review examines how modulating ROS levels and antioxidant status influences senescence, suggesting ROS may trigger this process in vivo.

Area of Science:

Cell Biology
Oxidative Stress Research
Aging Studies

Background:

Cellular senescence is a key process in aging and disease.
Reactive oxygen species (ROS) are implicated in various cellular functions and pathologies.
Existing evidence suggests a correlation between elevated intracellular ROS and the onset of senescence.

Purpose of the Study:

To review experimental evidence linking intracellular ROS levels to cellular senescence.
To explore the role of ROS modulation through oxygen concentrations and antioxidant status.
To discuss the potential involvement of ROS in oncogene-induced and in vivo senescence.

Main Methods:

Review of experimental studies modulating intracellular ROS levels.
Analysis of cellular responses to varying oxygen concentrations (high/low).

More Related Videos

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Related Experiment Videos

Last Updated: Jul 7, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Examination of studies perturbing cellular antioxidant status.

Main Results:

Experimental evidence supports a role for increased intracellular ROS in triggering senescence.
Senescence induced by oncogene expression is partially mediated by ROS.
Emerging evidence suggests ROS may also trigger senescence in vivo.

Conclusions:

Increased intracellular ROS is a significant factor contributing to cellular senescence.
Further research is needed to elucidate the precise mechanisms and specific ROS species involved in senescence induction.