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Updated: Jul 7, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Multiple sclerosis prevalence and possible lead exposure.

George Turabelidze¹, Mario Schootman, Bao-Ping Zhu

¹Missouri Department of Health and Senior Services, Jefferson City, MO, USA. George.Turabelidze@dhss.mo.gov

Journal of the Neurological Sciences

|February 20, 2008

Summary

This summary is machine-generated.

This study investigated multiple sclerosis (MS) prevalence in Jefferson County, Missouri. Findings indicate MS rates are comparable to national averages and do not cluster around the local lead smelter.

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Area of Science:

Epidemiology
Neurology
Environmental Health

Background:

Community concerns existed regarding a potential excess of multiple sclerosis (MS) cases in Jefferson County, Missouri.
A specific focus was placed on investigating a possible link between MS and an active lead smelter in the area.

Purpose of the Study:

To estimate the current prevalence of multiple sclerosis (MS) in Jefferson County, Missouri.
To determine if MS cases exhibit spatial clustering, particularly around a lead smelter.

Main Methods:

A five-year period (1998-2002) study population of Jefferson County residents was analyzed.
Capture-recapture analysis was employed for aggressive MS case finding, achieving 95% case ascertainment.
Spatial scan statistics were utilized to examine spatial clustering of MS cases.

Main Results:

The crude five-year period prevalence of MS was 105 per 100,000 population.
Age-standardized prevalence was 107 per 100,000, comparable to other US and Western European regions.
No significant spatial clusters of MS cases were identified within the study area, including around the lead smelter.

Conclusions:

The prevalence of multiple sclerosis in Jefferson County, Missouri, is comparable to national and international estimates.
There is no evidence to suggest that MS cases cluster around the local lead smelter.
Community concerns regarding an excess of MS linked to the lead smelter are not supported by the study findings.