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Can the basis for central neuropathic pain be identified by using a thermal grill?

Bud A D Craig1

  • 1Atkinson Research Laboratory, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ 85041, USA.

Pain
|February 20, 2008
PubMed
Abstract

No abstract available in PubMed .

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...