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Ghrelin - growth hormone releasing and orexigenic hormone in men declines with age, insulin and with decrease in
Jarosław Kozakowski1, Michał Rabijewski, Wojciech Zgliczyński
1Department of Endocrinology, Medical Center of Postgraduate Education, Bielanski Hospital, Warsaw, Poland. kyaroslaw@tlen.pl
Neuro Endocrinology Letters
|February 20, 2008
Summary
Serum ghrelin levels in men decrease with age and are lower than in women. Ghrelin also correlates negatively with insulin and positively with testosterone levels in men.
Area of Science:
- Endocrinology
- Human Physiology
Background:
- Ghrelin is a peptide hormone known for its growth hormone (GH)-releasing and appetite-stimulating effects.
- Understanding ghrelin's role in men's health is crucial for metabolic and endocrine research.
Purpose of the Study:
- To investigate the relationship between serum ghrelin levels and various physiological markers in men.
- Specifically, to examine correlations with age, weight, glucose metabolism, GH, IGF-1, and androgens.
Main Methods:
- The study included 19 healthy men aged 16-73 years.
- Measurements included height, weight, BMI, and serum concentrations of ghrelin, leptin, GH, IGF-1, glucose, insulin, estradiol, testosterone, and DHA-S.
Main Results:
- A significant negative correlation was observed between age and serum ghrelin levels in men (r=-0.52, p<0.04).
- Ghrelin levels were higher in men under 30 than over 60, and lower in men compared to women.
- Serum insulin levels showed a negative correlation with ghrelin (r=-0.87, p<0.0006), while testosterone levels showed a positive correlation (r=0.69, p<0.00006).
Conclusions:
- Serum ghrelin levels in men decline with age and are lower than in women.
- Ghrelin levels correlate negatively with fasting insulin and positively with testosterone in men.
- This study provides the first evidence of a correlation between serum testosterone and total ghrelin levels in men.
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